Characterization of hitherto unknown Valsartan photodegradation impurities
نویسندگان
چکیده
A detailed investigation of Valsartan`s light-induced degradation is reported. Based on UPLC-HRMS studies stressed solutions several pathways are proposed. Some the proposed structures were obtained by forced experiments. Examination analytical data including crystal allowed for structural revision one literature-known degradant. In addition, irradiation under aerobic conditions revealed further degradative leading to two previously unknown decomposition products. Mechanistic considerations regarding their origin helped identify weak points Valsartan influence light.
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ژورنال
عنوان ژورنال: Journal of Molecular Structure
سال: 2023
ISSN: ['0022-2860', '1872-8014']
DOI: https://doi.org/10.1016/j.molstruc.2022.134599